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LSD, peyote, psilocybin and PCP are drugs that cause hallucinations, ie, causing a deep distorted perception of reality. People who are under the influence of hallucinogens see images, hear sounds and feel sensations that seem real but are not. Some hallucinogens also produce rapid, intense emotional swings. LSD, peyote and psilocybin cause their effects initially disrupting the interaction of nerve cells and the neurotransmitter serotonin.

Despite the lack of controlled studies of adequate research on the specific effects of these drugs on the human brain, there have been smaller studies and several case reports documenting some of the effects associated with the use of hallucinogens:

LSD sense of time and identity are altered. Sensations may seem to "cross over" giving the user the feeling of hearing colors and seeing sounds. These changes can be frightening and can cause panic addict Some people have frightening thoughts and feelings of despair, afraid of losing control, of going crazy or dying when they are using this drug.